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Sulindac

Catalog No. T0459   CAS 38194-50-2
Synonyms: Arthrocine, MK-231, Clinoril, Sulindac sulfoxide

Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.

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Sulindac Chemical Structure
Sulindac, CAS 38194-50-2
Pack Size Availability Price/USD Quantity
50 mg In stock $ 40.00
100 mg In stock $ 47.00
200 mg In stock $ 66.00
500 mg In stock $ 97.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.49%
Purity: 99.32%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
In vitro In intestinal tissues of Min/+ mice, Sulindac does not alter the levels of PGE2 and LTB4 but reduces the number of tumors. Within a mouse model of familial adenomatous polyposis, Sulindac decreases small intestine COX-2 and prostaglandin E (2), thereby inhibiting tumor formation.
In vivo In colorectal cancer (CRC) cell lines, Sulindac and its metabolites sulindac sulfide and sulindac sulfone inhibit the NF-κB pathway, reducing IKKbeta kinase activity mediated by Sulindac. In HT-29 cells, Sulindac significantly reduces cell growth. Sulindac inhibits cell proliferation across various epithelial and fibroblast tumor cell lines. In CRC cell lines DLD1 and SW480, Sulindac suppresses beta-catenin/TCF-mediated gene transcription and decreases levels of non-phosphorylated beta-catenin.
Synonyms Arthrocine, MK-231, Clinoril, Sulindac sulfoxide
Molecular Weight 356.41
Formula C20H17FO3S
CAS No. 38194-50-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 9 mg/mL (25.25 mM)

DMSO: 66 mg/mL (185.2 mM)

TargetMolReferences and Literature

1. Yamamoto Y, et al. J Biol Chem,1999, 274(38), 27307-27314. 2. Piazza GA, et al. Cancer Res,1995, 55(14), 3110-3116. 3. Boon EM, et al. Br J Cancer. 2004 Jan 12;90(1):224-9. 4. Boolbol SK, et al. Cancer Res,1996, 56(11), 2556-2560. 5. Chiu CH, et al. Cancer Res,1997, 57(19), 4267-4273. 6. Gong EY, et al. Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells. Toxicol Lett. 2016 Sep 6;258:126-133. 7. Cha BK, et al. Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget. 2016 Aug 30;7(35):57213-57227.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Pediatric Drug Library FDA-Approved Drug Library Anti-Pancreatic Cancer Compound Library Anti-Liver Cancer Compound Library Drug Repurposing Compound Library Autophagy Compound Library

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Keywords

Sulindac 38194-50-2 Autophagy Immunology/Inflammation Neuroscience COX epithelial-mesenchymal transition (EMT) colorectal cancer (CRC) pMMR nonsteroidal MK231 SIRT1 oral inhibit Nuclear factor-kappaB TGF-β1 migration NSAID Arthrocine anti-inflammatory MK 231 NF-κB Nuclear factor-κB MK-231 lung cancer invasion Inhibitor FDA immunomodulatory agent Clinoril Sulindac sulfoxide inhibitor

 

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