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TG100-115

Catalog No. T2672   CAS 677297-51-7

TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.

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TG100-115 Chemical Structure
TG100-115, CAS 677297-51-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
5 mg In stock $ 77.00
10 mg In stock $ 117.00
25 mg In stock $ 222.00
50 mg In stock $ 397.00
100 mg In stock $ 619.00
500 mg In stock $ 1,280.00
1 mL * 10 mM (in DMSO) In stock $ 84.00
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Purity: 100%
Purity: 98.95%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.
Targets&IC50 PI3Kγ:83 nM
Kinase Assay PI3K assays: Forty mL of reaction buffer (20 mM Tris/4 mM MgCl2/10 mM NaCl, pH 7.4) containing 50 mM D-myo-phosphatidylinositol 4,5-bisphosphate substrate and the desired PI3K isoform are aliquoted to 96-well plates; kinase concentrations are 250-500 ng/well, such that linear kinetics are achieved over 90 min. TG100-115 is then added as 2.5 mL of a DMSO stock to final concentration range of 100 mM to 1 nM. Reactions are initiated by addition of 10 mL of ATP to a final concentration of 3 mM, and after 90 min, 50 mL of Kinase-Glo reagent added to quantify residual ATP levels; luminosity is measured using an Ultra 384 instrument. Control reactions omitting either TG100-115 or substrate are also performed. IC50 values are derived from experimental data by nonlinear curve fitting using Prism Version 4.
Cell Research Cells plated in 96-well cluster plates (5 × 103 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of TG100-115, and cell numbers are quantified by XTT assay 24, 48, or 72 hours late(Only for Reference)
Molecular Weight 346.34
Formula C18H14N6O2
CAS No. 677297-51-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 9 mg/mL (25.98 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Doukas J, et al. Proc Natl Acad Sci U S A, 2006, 103(52), 19866-119871. 2. Palanki MS, et al. J Med Chem, 2007, 50(18), 4279-4294. 3. Acevedo LM, et al. Blood, 2008, 111(5), 2674-2680. 4. Doukas J, et al. J Pharmacol Exp Ther, 2009, 328(3), 758-765.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library PI3K-AKT-mTOR Compound Library Anti-Pancreatic Cancer Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Glycolysis Compound Library Anti-Prostate Cancer Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets
PIK-75 Torkinib Dehydroglyasperin D PI-828 BEBT-908 PI3Kα-IN-14 PI3Kα-IN-13 PI3Kα-IN-12

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Keywords

TG100-115 677297-51-7 PI3K/Akt/mTOR signaling PI3K TG100 115 Phosphoinositide 3-kinase inhibit TG-100-115 Inhibitor TG100115 inhibitor

 

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