Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 46.00 | |
2 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 92.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 251.00 | |
50 mg | In stock | $ 375.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. |
Targets&IC50 | MTH1:0.8 nM |
In vitro | TH287 as first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 protein in cells.?Protein co-crystal structures demonstrate that the inhibitors bind in the active site of MTH1.?The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts[1]. |
Molecular Weight | 305.59 |
Formula | C11H11Cl3N4 |
CAS No. | 1638211-05-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (89.99 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TH287 hydrochloride 1638211-05-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis MTH1 inhibit Inhibitor TH287 TH287 Hydrochloride TH-287 Hydrochloride TH-287 hydrochloride TH 287 TH-287 TH 287 Hydrochloride inhibitor