Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 kinases, including other MAPKs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 70.00 | |
5 mg | In stock | $ 117.00 | |
10 mg | In stock | $ 187.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 kinases, including other MAPKs. |
Targets&IC50 | p38β:90 nM, p38α:9 nM |
In vitro | phosphorylation of p38 MAPK inhibited by Talmapimod (100-200 nM; 1 hour) in MM cells[1].In human whole blood, LPS-induced TNF-a production inhibited by Talmapimod [2]. Talmapimod decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells[3]. |
In vivo | Targeting p38α MAPK with Talmapimod (SCIO-469) decreases myeloma burden,and preventing the development of myeloma bone disease[2]. In 5T2MM and 5T33MM models,Talmapimod inhibits the growth of multiple myeloma and prevents bone diseases[3]. Talmapimod (10-90 mg/kg; p.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth and also dose-dependently reduced weight of the palpable tumors at termination[4]. |
Synonyms | SCIO-469 |
Molecular Weight | 513 |
Formula | C27H30ClFN4O3 |
CAS No. | 309913-83-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (185.19 mM)
You can also refer to dose conversion for different animals. More
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Talmapimod 309913-83-5 MAPK p38 MAPK cytotoxicity multiple inhibit tumor SCIO469 cells SCIO-469 Hsp27 Inhibitor phosphorylation SCIO 469 myeloma inhibitor