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Tazarotene

Catalog No. T6696 CAS 118292-40-3

Synonyms: Tazorac, AGN 190168, Zorac

Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.

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Tazarotene, CAS 118292-40-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 45.00
25 mg	In stock	$ 81.00
50 mg	In stock	$ 150.00
100 mg	In stock	$ 270.00
200 mg	In stock	$ 351.00
500 mg	In stock	$ 593.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.67%

Purity: 97.01%

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Storage & Solubility Information

Description	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
In vitro	Tazarotene causes ERK activation, RB tumor suppressor protein hypophosphorylation, G0 arrest, and myeloid differentiation in HL-60 human myeloblastic leukemia cells. Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective ligand. [1] Tazarotene therapy regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. [2] Tazarotene inhibits the proliferation of fibroblasts and synthesis of DNA and collagen. [3] Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. Tazarotene also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. [4] Tazarotene causes growth suppression in retinoid-responsive breast cancer cell lines by up-regulating TIG3. [5]
In vivo	Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in UV-treated Ptch1+/? mice. Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in ionizing radiation-treated Ptch1+/? mice. [5]

Synonyms	Tazorac, AGN 190168, Zorac
Molecular Weight	351.46
Formula	C21H21NO2S
CAS No.	118292-40-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35.2 mg/mL (100 mM)

Ethanol: 17.6 mg/mL (50 mM)

References and Literature

1. Yen A, et al. Mol Pharmacol, 2004, 66(6), 1727-1737. 2. Duvic M, et al. Expert Opin Investig Drugs, 1997, 6(10), 1537-1551. 3. Ogawa A, et al. Jpn J Pharmacol, 1998, 76(3), 317-319. 4. Duvic M, et al. J Am Acad Dermatol, 1997, 37(2 Pt 3), S18-24. 5. So PL, et al. Cancer Res, 2004, 64(13), 4385-4389. 6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Pediatric Drug Library Anti-Infection Compound Library Lipid Metabolism Compound Library Clinical Compound Library Human Metabolite Library

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Keywords

Tazarotene 118292-40-3 Autophagy Metabolism Retinoid Receptor inhibit Inhibitor RAR/RXR Retinoic acid receptors Tazorac AGN-190168 AGN 190168 Zorac AGN190168 Retinoid X receptors inhibitor

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