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Toloxatone

Catalog No. T5323 CAS 29218-27-7

Synonyms: MD 69276

Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAOA) inhibitor.

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Toloxatone, CAS 29218-27-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 327.00
100 mg	In stock	$ 559.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAOA) inhibitor.

In vivo

The maximum increase in systolic blood pressure produced by four single oral doses of tyramine administered during a meal and ranging from 100 mg to 800 mg was compared during repeated (3 to 5 days) administration of placebo, 200 mg toloxatone three times a day and 400 mg toloxatone three times a day in a single-blind, three-period crossover study. Toloxatone by itself had no significant influence on blood pressure. During administration of toloxatone, no significant increase in tyramine-induced increase in systolic blood pressure was observed for tyramine doses of 200 mg or less that are consistently higher than those associated with normal food intake [2].

Synonyms	MD 69276
Molecular Weight	207.23
Formula	C11H13NO3
CAS No.	29218-27-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (241.3 mM)

References and Literature

1. FMoureau, et al. A reversible monoamine oxidase inhibitor, toloxatone: spectrophotometric and molecular orbital studies of the interaction with flavin adenine dinucleotide (FAD). European Journal of Medicinal Chemistry. 1994, 29(4):269-277. 2. Provost JC, et al. Pharmacokinetic and pharmacodynamic interaction between toloxatone, a new reversible monoamine oxidase-A inhibitor, and oral tyramine in healthy subjects. Clin Pharmacol Ther. 1992 Oct;52(4):384-93.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Antidepressant Compound Library Neuronal Signaling Compound Library Approved Drug Library Reprogramming Compound Library Drug-Fragment Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Toloxatone 29218-27-7 Metabolism Neuroscience MAO Monoamine Oxidase MD69276 inhibit MD-69276 MD 69276 Inhibitor inhibitor

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