Shopping Cart
- Remove All
Your shopping cart is currently empty
Toloxatone
🥰Excellent
Catalog No. T5323Cas No. 29218-27-7
Alias MD 69276
Toloxatone (MD 69276) is a reversible inhibitor of monoamine oxidase A (MAOA).
Toloxatone
🥰Excellent
Purity: 99.86%
Catalog No. T5323Alias MD 69276Cas No. 29218-27-7
Toloxatone (MD 69276) is a reversible inhibitor of monoamine oxidase A (MAOA).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $52 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $189 | In Stock | |
| 50 mg | $327 | In Stock | |
| 100 mg | $559 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $57 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Toloxatone"
Paeonol
Peonol
T2900552-41-0
Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
- $46
Size
QTY
Hydroxyamine hydrochloride
Hydroxylammonium chloride, Hydroxylamine hydrochloride
T115875470-11-1
Hydroxyamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.Hydroxyamine hydrochloridee is an intermediate in organic synthesis and can be used to synthesize other active compounds.
- $31
Size
QTY
Methylene Blue trihydrate
Methylthionine chloride, Methylene Blue, Basic blue 9
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
- $42
Size
QTY
Azure B
Azure B chloride
T18918531-55-5
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
- $128
Size
QTY
Safinamide
FCE-26743, FCE26743, FCE 26743, EMD-1195686, EMD1195686, EMD 1195686
T6651L133865-89-1
Safinamide (FCE-26743) is a reversible and selective monoamine oxidase B (IC50 0.098μM) inhibitor, reducing the degradation of dopamine, and a glutamate release inhibitor (IC50 8μM). It also inhibits dopamine reuptake. Safinamide also blocks sodium and calcium channels. Potential additional uses of Safinamide might be Parkinson's disease, restless leg syndrome and epilepsy.
- $31
Size
QTY
Isatin
Pseudoisatin, Indoline-2,3-dione, 2,3-Indolinedione
T686291-56-5
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor.
- $29
Size
QTY
Hydralazine hydrochloride
Hydralazine HCl, Apresoline
T1613304-20-1
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
- $36
Size
QTY
Furazolidone
Cited
Furoxone
T075167-45-8
Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
- $40
Size
QTY
CitedMethylene Blue Cited
Tetramethylthionine chloride, methylthioninium chloride, CI-52015, Basic Blue 9
T688861-73-4
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
- $30
Size
QTY
Cited1,4-Naphthoquinone Cited
α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione
T7048130-15-4
1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
- $31
Size
QTY
CitedAllylthiourea
Thiosinamine, N-Allylthiourea
T0418109-57-9
Allylthiourea (Thiosinamine), a metabolic inhibitor, specifically suppresses ammonia oxidation.
- $29
Size
QTY
Linezolid
PNU-100766
T0391165800-03-3
Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.
- $43
Size
QTY
Select Batch
Purity:99.86%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Toloxatone (MD 69276) is a reversible inhibitor of monoamine oxidase A (MAOA). |
| In vivo | The maximum increase in systolic blood pressure produced by four single oral doses of tyramine administered during a meal and ranging from 100 mg to 800 mg was compared during repeated (3 to 5 days) administration of placebo, 200 mg toloxatone three times a day and 400 mg toloxatone three times a day in a single-blind, three-period crossover study. Toloxatone by itself had no significant influence on blood pressure. During administration of toloxatone, no significant increase in tyramine-induced increase in systolic blood pressure was observed for tyramine doses of 200 mg or less that are consistently higher than those associated with normal food intake [2]. |
| Alias | MD 69276 |
| Molecular Weight | 207.23 |
| Formula | C11H13NO3 |
| Cas No. | 29218-27-7 |
| Smiles | Cc1cccc(c1)N1CC(CO)OC1=O |
| Relative Density. | 1.245 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (241.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Toloxatone | purchase Toloxatone | Toloxatone cost | order Toloxatone | Toloxatone chemical structure | Toloxatone in vivo | Toloxatone formula | Toloxatone molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.