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Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $68 | In Stock | |
1 g | $100 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells. |
In vitro | Acetyl-trans-resveratrol inhibited cell viability, and induced apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner[1]. |
In vivo | Acetyl-trans-resveratrol significantly inhibited intracranial tumor growth and prolonged survival in these mouse models[2]. |
Cell Research | Apoptosis was determined by using apoptosis detection kit according to the manufacturers instructions.?Briefly, cells were treated with the indicated dosage of Acetyl-trans-resveratrol?for 48 h. The untreated and?treated cells were washed with PBS buffer and gently suspended in Annexin V binding buffer and incubated with Annexin V-FITC (20 μg/mL) and PI (20 μg/mL) for 15 minutes in the dark.?Flow cytometry analysis was performed using Cellquest software. |
Alias | Acetyl-trans-resveratrol |
Molecular Weight | 354.35 |
Formula | C20H18O6 |
Cas No. | 42206-94-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (141.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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