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Tyr-Gly-Gly-Phe-Met-OH

Catalog No. T7211 CAS 58569-55-4

Synonyms: Methionine enkephalin, Met-Enkephalin

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.

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Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

Tyr-Gly-Gly-Phe-Met-OH, CAS 58569-55-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
25 mg	In stock	$ 86.00
50 mg	In stock	$ 139.00
100 mg	In stock	$ 219.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 98%

Biological Description

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Description

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.

In vitro

Tyr-Gly-Gly-Phe-Met-OH,as know as Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems.?MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells.?Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs).?MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells.?All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy.?Furthermore, they reveal a relationship between the endocrine and immune systems.

Synonyms	Methionine enkephalin, Met-Enkephalin
Molecular Weight	573.66
Formula	C27H35N5O7S
CAS No.	58569-55-4

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (69.73 mM)

References and Literature

1. Zhao D , Plotnikoff N , Griffin N , et al. Methionine enkephalin, its role in immunoregulation and cancer therapy[J]. International Immunopharmacology, 2016:S1567576916300509.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Peptide Compound Library Anti-Parkinson's Disease Compound Library Bioactive Compound Library Anti-Cancer Compound Library Anti-COVID-19 Compound Library Neuronal Signaling Compound Library

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Keywords

Tyr-Gly-Gly-Phe-Met-OH 58569-55-4 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Inhibitor Tyr Gly Gly Phe Met OH Methionine enkephalin TyrGlyGlyPheMetOH Met-Enkephalin inhibit inhibitor

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