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UNC2025

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Purity:99.74%

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COA HNMR HPLC

UNC2025

Catalog No. T7007Cas No. 1429881-91-3

UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.

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Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$52	In Stock
10 mg	$85	In Stock
25 mg	$126	In Stock
50 mg	$207	In Stock
100 mg	$369	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Product Introduction

Bioactivity

Description	UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.
In vitro	In 697 B-ALL cells, UNC-2025 potently inhibits Mer phosphorylation with IC50 of 2.7 nM. In A549 NSCLC and Molm-14 AML cell lines, UNC-2025 causes significant inhibition of colony formation dependent on Mer8 and Flt3. [1] In H2228 and H1299 cell lines, UNC-2025 inhibits MERTK oncogenic signaling downstream, such as basal and stimulated pAKT and pERK1/2. In four NSCLC cell lines, UNC-2025 also induces apoptotic cell death, and decreases colony formation. [2]
In vivo	In mice bearing 697 acute leukemia tumors, UNC-2025 (3 mg/kg, p.o.) shows good solubility and DMPK properties, and results in effective target inhibition. [1] In mice bearing H2228 or A549 tumors, UNC-2025 (50 mg/kg, p.o.) inhibits tumor growth. [2]
Alias	mrx-6313, UNC-2025, UNC 2025

Chemical Properties

Molecular Weight	476.66
Formula	C28H40N6O
Cas No.	1429881-91-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: 8 mg/mL(15.59 mM)

DMSO: 6.25 mg/mL (13.11 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0979 mL	10.4897 mL	20.9793 mL	104.8966 mL
5 mM	0.4196 mL	2.0979 mL	4.1959 mL	20.9793 mL
10 mM	0.2098 mL	1.0490 mL	2.0979 mL	10.4897 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1049 mL	0.5245 mL	1.0490 mL	5.2448 mL
50 mM	0.0420 mL	0.2098 mL	0.4196 mL	2.0979 mL
100 mM	0.0210 mL	0.1049 mL	0.2098 mL	1.0490 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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