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VAS2870

Catalog No. T4359 CAS 722456-31-7

VAS2870 is an inhibitor of NADPH oxidase (NOX).

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VAS2870, CAS 722456-31-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 345.00
100 mg	In stock	$ 516.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 97.49%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

VAS2870 is an inhibitor of NADPH oxidase (NOX).

In vitro

VAS2870 effectively inhibits the growth and proliferation of FaO rat hepatoma cells and various human hepatocellular carcinoma (HCC) cell lines, while also enhancing TGF-b-mediated apoptosis in these cells. It suppresses the activation of NADPH oxidase and the production of intracellular ROS induced by PDGF-BB, without affecting DNA synthesis. Preincubation with VAS2870 at concentrations of 10 and 20 μM completely prevents PDGF-mediated NADPH oxidase activation and ROS production, although it does not interfere with PDGF-induced cell cycle progression. However, VAS2870 does effectively eliminate PDGF-dependent chemotaxis of VSMC, achieving 100% inhibition at 10 μM. Additionally, VAS2870 dose-dependently reduces autocrine cell number increases in FaO rat hepatoma cells, and at 25 mM, it almost completely blocks ROS production and thymidine incorporation.

Molecular Weight	360.39
Formula	C18H12N6OS
CAS No.	722456-31-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3 mg/mL (231.14 mM), Sonification is recommended.

References and Literature

1. ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71(2):331-41. 2. Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ferroptosis Compound Library Anti-Aging Compound Library Anti-Cardiovascular Disease Compound Library Preclinical Compound Library Mitochondria-Targeted Compound Library Human Metabolite Library NO PAINS Compound Library Lipid Metabolism Compound Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VAS2870 722456-31-7 Metabolism NADPH NADPH Oxidase NOX inhibit VAS 2870 VAS-2870 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.