Shopping Cart
- Remove All
Your shopping cart is currently empty
VY-3-135
🥰Excellent
Catalog No. T9732Cas No. 1824637-41-3
VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
VY-3-135
🥰Excellent
Purity: 99.25%
Catalog No. T9732Cas No. 1824637-41-3
VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 92 € | In Stock | |
| 5 mg | 187 € | In Stock | |
| 10 mg | 311 € | In Stock | |
| 25 mg | 530 € | In Stock | |
| 50 mg | 748 € | In Stock | |
| 100 mg | 1.064 € | In Stock | |
| 500 mg | 2.118 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 227 € | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "VY-3-135"
Orlistat
Cited
Tetrahydrolipstatin, Ro-18-0647
T068696829-58-2
Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.
- 49 €
Size
QTY
CitedL-Carnitine
Levocarnitine, L(-)-Carnitine
T0846541-15-1
L-Carnitine (L(-)-Carnitine) is an amino acid derivative. L-Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain.
- 28 €
Size
QTY
Betulin Cited
Trochol, Betulol, betulinol, betulinic alcohol, betuline
T3121473-98-3
Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well.
- 31 €
Size
QTY
Citedtrans-Chalcone
Cinnamophenone, Chalkone, Chalcone
T3322614-47-1
trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
- 28 €
Size
QTY
Pyrazinamide
Pyrazinoic acid amide, Pyrazinecarboxamide
T142698-96-4
Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
- 42 €
Size
QTY
A-769662 Cited
A 769662
T2468844499-71-4
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
- 31 €
Size
QTY
CitedDenifanstat
Cited
TVB-2640, TVB2640, FASN-IN-2
T152711399177-37-7
Denifanstat (FASN-IN-2) is a fatty acid synthase (FASN) inhibitor (IC50=0.052 μM, EC50=0.072 μM) with selective and oral activity. Denifanstat has been used in studies of steatohepatitis.
- 78 €
Size
QTY
CitedTVB-3664
T171812097262-58-1
TVB-3664 is an orally active, selective, reversible, and highly bioavailable fatty acid synthase inhibitor (FASN) with an IC50 for palmitate synthesis of 18 nM in human and 12 nM in mouse.Significantly inhibits microtubule protein palmitoylation and mRNA expression.
- 116 €
Size
QTY
Lycorine Cited
Narcissine, Licorine, Galanthidine, Belamarine, Amarylline
T3324476-28-8
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
- 28 €
Size
QTY
CitedFASN-IN-1
TVB-2460
T112671808260-84-5In house
FASN-in-1 is an effective, specific inhibitor of fatty acid synthase (FASN), a compound specifically designed to target and inhibit the activity of the enzyme involved in fatty acid synthesis, potentially disrupting fatty acid production and affecting various cellular processes.
- 57 €
Size
QTY
Fatostatin hydrobromide Cited
Fatostatin HBr
T6832298197-04-3
Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
- 40 €
Size
QTY
CitedTrimetazidine dihydrochloride Cited
Yoshimilon, Vastarel F, Kyurinett
T098813171-25-0
Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in ischemic heart disease or angina.
- 32 €
Size
QTY
CitedSelect Batch
Purity:99.25%
Contact us for more batch information
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, showing no inhibitory activity against recombinant human ACSS1 or ACSS3. VY-3-135 can effectively inhibit ACSS2-dependent fatty acid metabolism but has no effect on gene expression in tumors. |
| In vitro | METHODS: BT474 cells were treated with VY-3-135 (0.01, 0.1, 1 μM), and SKBr3 cells were treated with VY-3-135 (1 μM). RESULTS VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells. VY-3-135 is an effective targeted ACSS2 inhibitor in cells. [1] |
| In vivo | METHODS: BT474-transplanted mice were randomly assigned and treated with VY-3-135 (100 mg/kg) by intraperitoneal (IP) injection or oral gavage. Tumor size was measured in mice. RESULTS VY-3-135 inhibited the growth of MDA-MB-468 (ACSS2 high) tumors but had no effect on WHIM12 (ACSS2 low) tumors. [1] |
| Molecular Weight | 429.51 |
| Formula | C26H27N3O3 |
| Cas No. | 1824637-41-3 |
| Smiles | CCn1c(nc2ccc(cc12)C(=O)NC[C@@H](C)O)C(O)(c1ccccc1)c1ccccc1 |
| Relative Density. | 1.21 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (116.41 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy VY-3-135 | purchase VY-3-135 | VY-3-135 cost | order VY-3-135 | VY-3-135 chemical structure | VY-3-135 in vivo | VY-3-135 in vitro | VY-3-135 formula | VY-3-135 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.