Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 117.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 747.00 | |
200 mg | In stock | $ 987.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 5 mM (in DMSO) | In stock | $ 163.00 |
Description | XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM. |
Targets&IC50 | CDC7:3.4 nM, Pim1:42 nM, CK2:212 nM |
In vitro | XL413 (BMS-863233) hydrochloride effectively inhibits cell proliferation (IC 50 = 2685 nM), reduces cell viability (IC 50 = 2142 nM), and increases caspase 3/7 activity (EC 50 = 2288 nM) in Colo-205 cells. Additionally, it significantly suppresses the anchorage-independent growth of Colo-205 cells in soft agar (IC 50 = 715 nM) [1]. Demonstrating cytotoxic effects, XL413 hydrochloride has IC 50 values of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. It triggers apoptosis in Colo-205 cells without affecting HCC1954 cells. As a DDK inhibitor, XL413 shows potent activity in vitro (IC 50 = 22.7 nM), yet fails to inhibit DDK-dependent Mcm2 phosphorylation in HCC1954 cells, while remaining effective in Colo-205 cells [2]. |
In vivo | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride exhibits excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses without significant body weight loss [1]. |
Synonyms | BMS-863233 Hydrochloride, XL413, BMS-863233 |
Molecular Weight | 326.18 |
Formula | C14H13Cl2N3O2 |
CAS No. | 2062200-97-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL (7.66 mM)
H2O: 4.76 mg/mL (14.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
XL413 hydrochloride 2062200-97-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein JAK/STAT signaling Metabolism Stem Cells CDK cholecystokinin Casein Kinase Pim BMS-863233 Hydrochloride XL-413 hydrochloride XL 413 Hydrochloride XL413 BMS 863233 Hydrochloride BMS863233 Hydrochloride BMS863233 XL 413 XL-413 Hydrochloride XL-413 XL413 Hydrochloride BMS 863233 BMS-863233 inhibitor inhibit