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YF-2

YF-2
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Catalog No. T5468Cas No. 1311423-89-8
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Purity:99.33%
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YF-2

Purity: 99.33%
Catalog No. T5468Cas No. 1311423-89-8

YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$73In Stock
10 mg$118In Stock
25 mg$248In Stock
50 mg$371In Stock
100 mg$527In Stock
200 mg$726In Stock
1 mL x 10 mM (in DMSO)$80In Stock
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Product Introduction

Bioactivity
Description
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Targets&IC50
GCN5:49.31 μM, PCAF:29.04 μM , CBP:2.75 μM
In vitro
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells, respectively.
In vivo
YF-2, administered intraperitoneally at doses of 20 mg/kg (2 hours before an electric shock) or 5 mg/kg (30 minutes prior to the electric shock), effectively rescues the defect in contextual memory in mice. At a dosage of 20 mg/kg without the electric shock treatment, YF-2 exhibits no impact on contextual memory in mice.
Chemical Properties
Molecular Weight430.85
FormulaC20H22ClF3N2O3
Cas No.1311423-89-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 125 mg/mL (290.12 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3210 mL11.6050 mL23.2099 mL116.0497 mL
5 mM0.4642 mL2.3210 mL4.6420 mL23.2099 mL
10 mM0.2321 mL1.1605 mL2.3210 mL11.6050 mL
20 mM0.1160 mL0.5802 mL1.1605 mL5.8025 mL
50 mM0.0464 mL0.2321 mL0.4642 mL2.3210 mL
100 mM0.0232 mL0.1160 mL0.2321 mL1.1605 mL

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