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YF-2

Catalog No. T5468Cas No. 1311423-89-8

YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively

YF-2

YF-2

Purity: 99.33%
Catalog No. T5468Cas No. 1311423-89-8
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$413In Stock
50 mg$618In Stock
100 mg$879In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Purity:99.33%
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Product Introduction

Bioactivity
Description
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Targets&IC50
GCN5:49.31 μM, PCAF:29.04 μM , CBP:2.75 μM
In vitro
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells, respectively.
In vivo
YF-2, administered intraperitoneally at doses of 20 mg/kg (2 hours before an electric shock) or 5 mg/kg (30 minutes prior to the electric shock), effectively rescues the defect in contextual memory in mice. At a dosage of 20 mg/kg without the electric shock treatment, YF-2 exhibits no impact on contextual memory in mice.
Chemical Properties
Molecular Weight430.85
FormulaC20H22ClF3N2O3
Cas No.1311423-89-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 125 mg/mL (290.12 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3210 mL11.6050 mL23.2099 mL116.0497 mL
5 mM0.4642 mL2.3210 mL4.6420 mL23.2099 mL
10 mM0.2321 mL1.1605 mL2.3210 mL11.6050 mL
20 mM0.1160 mL0.5802 mL1.1605 mL5.8025 mL
50 mM0.0464 mL0.2321 mL0.4642 mL2.3210 mL
100 mM0.0232 mL0.1160 mL0.2321 mL1.1605 mL

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