Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

YF-2

🥰Excellent
Catalog No. T5468Cas No. 1311423-89-8

YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively

YF-2

YF-2

🥰Excellent
Purity: 99.33%
Catalog No. T5468Cas No. 1311423-89-8
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$413In Stock
50 mg$618In Stock
100 mg$879In Stock
1 mL x 10 mM (in DMSO)$133In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "YF-2"

Select Batch
Purity:99.33%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
Targets&IC50
GCN5:49.31 μM, PCAF:29.04 μM , CBP:2.75 μM
In vitro
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells, respectively.
In vivo
YF-2, administered intraperitoneally at doses of 20 mg/kg (2 hours before an electric shock) or 5 mg/kg (30 minutes prior to the electric shock), effectively rescues the defect in contextual memory in mice. At a dosage of 20 mg/kg without the electric shock treatment, YF-2 exhibits no impact on contextual memory in mice.
Chemical Properties
Molecular Weight430.85
FormulaC20H22ClF3N2O3
Cas No.1311423-89-8
SmilesCCOc1cccc(OCCN(C)C)c1C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Relative Density.1.285 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 125 mg/mL (290.12 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3210 mL11.6050 mL23.2099 mL116.0497 mL
5 mM0.4642 mL2.3210 mL4.6420 mL23.2099 mL
10 mM0.2321 mL1.1605 mL2.3210 mL11.6050 mL
20 mM0.1160 mL0.5802 mL1.1605 mL5.8025 mL
50 mM0.0464 mL0.2321 mL0.4642 mL2.3210 mL
100 mM0.0232 mL0.1160 mL0.2321 mL1.1605 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy YF-2 | purchase YF-2 | YF-2 cost | order YF-2 | YF-2 chemical structure | YF-2 in vivo | YF-2 in vitro | YF-2 formula | YF-2 molecular weight