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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $50 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $618 | In Stock | |
100 mg | $879 | In Stock | |
1 mL x 10 mM (in DMSO) | $133 | In Stock |
Description | YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively |
In vitro | YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells, respectively. |
In vivo | YF-2, administered intraperitoneally at doses of 20 mg/kg (2 hours before an electric shock) or 5 mg/kg (30 minutes prior to the electric shock), effectively rescues the defect in contextual memory in mice. At a dosage of 20 mg/kg without the electric shock treatment, YF-2 exhibits no impact on contextual memory in mice. |
Molecular Weight | 430.85 |
Formula | C20H22ClF3N2O3 |
Cas No. | 1311423-89-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 125 mg/mL (290.12 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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