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YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $52 | In Stock | |
2 mg | $76 | In Stock | |
5 mg | $127 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $349 | In Stock | |
50 mg | $499 | In Stock | |
100 mg | $690 | In Stock | |
500 mg | $1,370 | In Stock | |
1 mL x 10 mM (in DMSO) | $131 | In Stock |
Description | YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation. |
In vitro | The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively. |
Alias | C24 |
Molecular Weight | 465.93 |
Formula | C29H20ClNO3 |
Cas No. | 1273323-67-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (193.2 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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