Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 87.00 | |
2 mg | In stock | $ 127.00 | |
5 mg | In stock | $ 213.00 | |
10 mg | In stock | $ 343.00 | |
25 mg | In stock | $ 583.00 | |
50 mg | In stock | $ 833.00 | |
100 mg | In stock | $ 1,150.00 | |
500 mg | In stock | $ 2,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 219.00 |
Description | YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation. |
In vitro | The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively. |
Synonyms | C24 |
Molecular Weight | 465.93 |
Formula | C29H20ClNO3 |
CAS No. | 1273323-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90mg/mL (193.2mM)
You can also refer to dose conversion for different animals. More
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YLF-466D 1273323-67-3 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK C24 C-24 C 24 inhibitor inhibit