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YLF-466D

Catalog No. T13368Cas No. 1273323-67-3
Alias C24

YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.

YLF-466D

YLF-466D

Purity: 98.04%
Catalog No. T13368Alias C24Cas No. 1273323-67-3
YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
2 mg$76In Stock
5 mg$127In Stock
10 mg$198In Stock
25 mg$349In Stock
50 mg$499In Stock
100 mg$690In Stock
500 mg$1,370In Stock
1 mL x 10 mM (in DMSO)$131In Stock
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Purity:98.04%
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Product Introduction

Bioactivity
Description
YLF-466D (C24) is a novel AMPK activator that inhibits platelet aggregation.
In vitro
The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively.
AliasC24
Chemical Properties
Molecular Weight465.93
FormulaC29H20ClNO3
Cas No.1273323-67-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (193.2 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1462 mL10.7312 mL21.4625 mL107.3123 mL
5 mM0.4292 mL2.1462 mL4.2925 mL21.4625 mL
10 mM0.2146 mL1.0731 mL2.1462 mL10.7312 mL
20 mM0.1073 mL0.5366 mL1.0731 mL5.3656 mL
50 mM0.0429 mL0.2146 mL0.4292 mL2.1462 mL
100 mM0.0215 mL0.1073 mL0.2146 mL1.0731 mL

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