Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 272.00 | |
5 mg | In stock | $ 569.00 | |
10 mg | In stock | $ 816.00 | |
25 mg | In stock | $ 1,250.00 | |
50 mg | In stock | $ 1,680.00 | |
100 mg | In stock | $ 2,270.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 589.00 |
Description | ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. |
Targets&IC50 | Plasmin:1850 nM , uPA:237 nM , TPA:1600 nM |
In vivo | In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h[1]. |
Molecular Weight | 414.4 |
Formula | C22H20F2N2O4 |
CAS No. | 2254001-81-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/ml (28.96 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ZK824190 2254001-81-3 Others Proteases/Proteasome Serine Protease Inhibitor Serine endopeptidases protease multiple sclerosis plasminogen Urokinase Plasminogen activator inhibitor-1 Serine Serine proteases Ser/Thr Protease ZK-824190 uPA Threonine proteases ZK 824190 inhibit PAI-1 inhibitor