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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $272 | In Stock | |
5 mg | $569 | In Stock | |
10 mg | $816 | In Stock | |
25 mg | $1,250 | In Stock | |
50 mg | $1,680 | In Stock | |
100 mg | $2,270 | In Stock | |
1 mL x 10 mM (in DMSO) | $589 | In Stock |
Description | ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA), with IC50 values of 237 nM for uPA, 1600 nM for tPA, and 1850 nM for Plasmin. |
In vivo | In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h[1]. |
Molecular Weight | 414.4 |
Formula | C22H20F2N2O4 |
Cas No. | 2254001-81-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 12 mg/ml (28.96 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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