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ZM39923 hydrochloride

Catalog No. T6145 CAS 1021868-92-7

Synonyms: JAK3 Inhibitor IV, ZM 39923 HCl

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

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ZM39923 hydrochloride Chemical Structure

ZM39923 hydrochloride, CAS 1021868-92-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 54.00
10 mg	In stock	$ 96.00
25 mg	In stock	$ 179.00
50 mg	In stock	$ 327.00
100 mg	In stock	$ 488.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

In vitro

The selectivity of Rotigotine for D3 (pKi 9.2) receptors is higher 10-fold than D2/D4/D5 (pKi 8.5-8.0) and 100-fold than D1 receptors (pKi 7.2). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. In functional studies, Rotigotine behaves as a full agonist at all dopamine receptors but notably, the potency for stimulation of D1 receptors is similar to that for D2/D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.

Synonyms	JAK3 Inhibitor IV, ZM 39923 HCl
Molecular Weight	367.91
Formula	C23H25NO·HCl
CAS No.	1021868-92-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 8 mg/mL (21.74 mM)

DMSO: 28 mg/mL (76.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Brown GR, et al. Bioorg Med Chem Lett. 2000, 10(6), 575-579. 2. Lai TS, et al. Chem Biol, 2008, 15(9), 969-978.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Obesity Compound Library NO PAINS Compound Library Covalent Inhibitor Library JAK-STAT Compound Library Anti-Colorectal Cancer Compound Library Stem Cell Differentiation Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ZM39923 hydrochloride 1021868-92-7 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Others Stem Cells Tyrosine Kinase/Adaptors EGFR JAK JAK3 Inhibitor IV inhibit ZM 39923 ZM 39923 HCl Janus kinase ZM-39923 hydrochloride ZM39923 Hydrochloride ZM-39923 Inhibitor ZM-39923 Hydrochloride ZM 39923 Hydrochloride ZM39923 inhibitor

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