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Zopolrestat

Catalog No. T35317 CAS 110703-94-1

Synonyms: CP 73850, CP73850, CP-73850, Zopolrestatum

Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Zopolrestat, CAS 110703-94-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 40.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 93.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 345.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Targets&IC50	Aldose reductase:3.1 nM
In vitro	Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1].
In vivo	After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1].

Synonyms	CP 73850, CP73850, CP-73850, Zopolrestatum
Molecular Weight	419.38
Formula	C19H12F3N3O3S
CAS No.	110703-94-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (26.23 mM), Sonication is recommended.

References and Literature

1. Mylari BL, et al. Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. J Med Chem. 1991;34(1):108-122. 2. Zhai J, et al. Zopolrestat as a human glyoxalase I inhibitor and its structural basis. ChemMedChem. 2013 Sep;8(9):1462-4. 3. Badawy D, et al. Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity. Can J Physiol Pharmacol. 2013 Feb;91(2):101-7. 4. Ramasamy R, et al. Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat. Cardiovasc Res. 1999 Apr;42(1):130-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Endocrinology-Hormone Compound Library Bioactive Compound Library Orally Active Compound Library Metabolism Compound Library Bioactive Compounds Library Max Human Metabolite Library

Related Products

Related compounds with same targets

Sorbinil Quercetin 3-gentiobioside Risarestat Minalrestat Isomer-Turosteride 2'-acetylacteoside 12-O-Methylcarnosic acid Alrestatin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zopolrestat 110703-94-1 Endocrinology/Hormones Metabolism Reductase diabetic potent CP 73850 glyceraldehyde CP73850 glucose aldose CP-73850 rats inhibit Aldose Reductase Inhibitor Zopolrestatum oral inhibitor

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