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Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $77 | In Stock | |
2 mg | $109 | In Stock | |
5 mg | $170 | In Stock | |
10 mg | $298 | In Stock | |
25 mg | $491 | In Stock | |
50 mg | $729 | In Stock | |
100 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $198 | In Stock |
Description | Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2). |
Targets&IC50 | TYK2:1253 nM, JAK1:29 nM, JAK2:803 nM |
In vitro | Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively. |
In vivo | In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling. |
Alias | PF-04965842 |
Molecular Weight | 323.41 |
Formula | C14H21N5O2S |
Cas No. | 1622902-68-4 |
Smiles | CCCS(=O)(=O)N[C@H]1C[C@H](C1)N(C)c1ncnc2[nH]ccc12 |
Relative Density. | 1.36 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (371.05 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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