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Ac-YVAD-CHO
🥰Excellent
Catalog No. T19883Cas No. 143313-51-3
Alias L-709049, L709049, L 709049
Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.
Ac-YVAD-CHO
🥰Excellent
Catalog No. T19883Alias L-709049, L709049, L 709049Cas No. 143313-51-3
Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $428 | In Stock | |
| 25 mg | $698 | In Stock | |
| 50 mg | $968 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum. |
| Targets&IC50 | IL-1β (mouse):2.5 μM, IL-1β (human):0.7 μM |
| In vitro | Ac-YVAD-CHO reduced the elevation of IL-1β in LPS-treated plasma and peritoneal fluid.Ac-YVAD-CHO inhibited IL-1β with IC50=2.5 μM (mouse) and IC50=0.7 μM (human) in both mouse and human. [1] 15.6 μM Ac-YVAD-CHO inhibited NO-induced PARP cleavage and reduced NO-induced apoptosis in SNAP-treated thymocytes. [2] |
| In vivo | 30 mg/kg intraperitoneal injection of Ac-YVAD-CHO inhibited IL-1β levels in the blood of P. acnes sensitized mice. [1] Intrastriatal infusion of 2-8 μg Ac-YVAD-CHO attenuated quinolinic acid (QA)-induced apoptosis in rat striatum. [3] |
| Alias | L-709049, L709049, L 709049 |
| Molecular Weight | 492.52 |
| Formula | C23H32N4O8 |
| Cas No. | 143313-51-3 |
| Smiles | [C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)(C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C)=O)C(C)C |
| Relative Density. | 1.276 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL(101.52 mM) DMSO: 2 mg/mL(4.06 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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