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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $47 | In Stock | |
10 mg | $77 | In Stock | |
25 mg | $163 | In Stock | |
50 mg | $279 | In Stock | |
100 mg | $420 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells. |
In vitro | AK-1 induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.AK-1 (5 μM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures[1]. |
Molecular Weight | 403.45 |
Formula | C19H21N3O5S |
Cas No. | 330461-64-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (99.14 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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