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Alda-1

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Purity:100%

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COA LCMS HPLC HNMR

Alda-1

Catalog No. T2662Cas No. 349438-38-6

Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).

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Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$56	In Stock
25 mg	$71	In Stock
50 mg	$89	In Stock
100 mg	$158	In Stock
200 mg	$205	In Stock
500 mg	$466	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Product Introduction

Bioactivity

Description	Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH21 and the Asian E487K mutant ALDH22 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
Kinase Assay	Lipid kinase activity : IC50 values are measured using a standard lipid kinase activity with PI as a substrate. (i)100 μM cold ATP is used instead of 10 μM, (ii) the DMSO concentration is 1%, and (iii) [γ-33P]ATP is used instead of [γ-32P]ATP. The TLC plates are quantified using a phosphorimager screen. The reported IC50 values are determined by non-linear regression analysis on the basis of at least three independent experiments repeated across multiple preparations of recombinant protein.
Cell Research	Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5 μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96-well plates at final volume of 0.2 mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]-thymidine per well at 16 h before the end of the incubation. The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillation counter.
Alias	Alda 1

Chemical Properties

Molecular Weight	324.16
Formula	C15H11Cl2NO3
Cas No.	349438-38-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (169.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0849 mL	15.4245 mL	30.8490 mL	154.2448 mL
5 mM	0.6170 mL	3.0849 mL	6.1698 mL	30.8490 mL
10 mM	0.3085 mL	1.5424 mL	3.0849 mL	15.4245 mL
20 mM	0.1542 mL	0.7712 mL	1.5424 mL	7.7122 mL
50 mM	0.0617 mL	0.3085 mL	0.6170 mL	3.0849 mL
100 mM	0.0308 mL	0.1542 mL	0.3085 mL	1.5424 mL

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