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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $40 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $106 | In Stock | |
25 mg | $176 | In Stock | |
50 mg | $262 | In Stock | |
100 mg | $389 | In Stock |
Description | Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis. |
In vitro | Anti-inflammatory agent 51 (compound 11d) effectively reduces the release of IL-6 (IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM), and decreases the mRNA levels of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 to the nucleus [1]. |
In vivo | Anti-inflammatory agent 51 (compound 11d) improves lipopolysaccharide (LPS)-induced acute lung injury (ALI) and alleviates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice [1]. |
Molecular Weight | 498.51 |
Formula | C22H22N6O6S |
Cas No. | 2911610-03-0 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (120.36 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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