Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC 50 value of 7.6 nM. ART812 has an IC 50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ).
Description | ART812 is an orally active DNA polymerase Polθ inhibitor with an IC 50 value of 7.6 nM. ART812 has an IC 50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ). |
Targets&IC50 | Polθ:7.6 nM (IC50) |
In vitro | ART812 (0-40 μM) elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells [1] . |
In vivo | ART812 (100?mg/kg; p.o. daily for 76 days) shows significant tumour inhibition in rats bearing established MDA-MB-436 BRCA1/SHLD2 defective tumours (volume 250-350?mm 3 ) [1] . |
Molecular Weight | 461.8 |
Formula | C19H16ClF4N3O4 |
CAS No. | 2607138-82-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 90.0 mg/mL (194.9 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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ART812 2607138-82-7 ART-812 Inhibitor inhibitor inhibit