store at low temperature
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
Description | ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM. |
Targets&IC50 | Polθ:7.6 nM (IC50) |
In vitro | ART812 (0-40 μM) elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells [1] . |
In vivo | ART812 (100?mg/kg; p.o. daily for 76 days) shows significant tumour inhibition in rats bearing established MDA-MB-436 BRCA1/SHLD2 defective tumours (volume 250-350?mm 3 ) [1] . |
Molecular Weight | 461.8 |
Formula | C19H16ClF4N3O4 |
CAS No. | 2607138-82-7 |
store at low temperature
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 90.0 mg/mL (194.9 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ART812 2607138-82-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis ART-812 Inhibitor inhibitor inhibit