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AS1269574

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Purity:99.98%

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COA HPLC HNMR

AS1269574

Catalog No. T21623Cas No. 330981-72-1

AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.

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Pack Size	Price	Availability
2 mg	$41	In Stock
5 mg	$64	In Stock
10 mg	$109	In Stock
25 mg	$207	In Stock
50 mg	$328	In Stock
100 mg	$490	In Stock
500 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Product Introduction

Bioactivity

Description	AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.
In vitro	AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions.?This contrasted with the action of the sulfonylurea glibenclamide, which also induced insulin secretion under low-glucose conditions (2.8mM)[1].
In vivo	In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles.?Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice.?AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes[1].
Alias	AS 1269574

Chemical Properties

Molecular Weight	308.17
Formula	C13H14BrN3O
Cas No.	330981-72-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (811.24 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2450 mL	16.2248 mL	32.4496 mL	162.2481 mL
5 mM	0.6490 mL	3.2450 mL	6.4899 mL	32.4496 mL
10 mM	0.3245 mL	1.6225 mL	3.2450 mL	16.2248 mL
20 mM	0.1622 mL	0.8112 mL	1.6225 mL	8.1124 mL
50 mM	0.0649 mL	0.3245 mL	0.6490 mL	3.2450 mL
100 mM	0.0324 mL	0.1622 mL	0.3245 mL	1.6225 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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