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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $65 | In Stock | |
2 mg | $93 | In Stock | |
5 mg | $143 | In Stock | |
10 mg | $196 | In Stock | |
25 mg | $389 | In Stock | |
50 mg | $590 | In Stock | |
100 mg | $859 | In Stock | |
1 mL x 10 mM (in DMSO) | $198 | In Stock |
Description | AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively. |
Targets&IC50 | BCL2:17 nM(KPUM-UH1 cells), BCL-XL:17 nM(KPUM-UH1 cells) |
In vitro | AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines. And it profoundly increases cells undergoing apoptosis in all three cell lines[1]. AZD4320 potently augments the antitumor effect of AZD5153 in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. |
Molecular Weight | 945.53 |
Formula | C45H48ClF3N4O7S3 |
Cas No. | 1357576-48-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (132.20 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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