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Balipodect

🥰Excellent
Catalog No. T1745Cas No. 1238697-26-1
Alias TAK-063, TAK063, TAK 063

Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.

Balipodect

Balipodect

🥰Excellent
Purity: 99.28%
Catalog No. T1745Alias TAK-063, TAK063, TAK 063Cas No. 1238697-26-1
Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.
Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
2 mg$45In Stock
5 mg$72In Stock
10 mg$94In Stock
25 mg$158In Stock
50 mg$270In Stock
100 mg$468In Stock
1 mL x 10 mM (in DMSO)$72In Stock
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Purity:99.28%
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Product Introduction

Bioactivity
Description
Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.
Targets&IC50
PDE10A:0.3 nM
In vivo
TAK-063 has high brain penetration in mice. Oral administration of TAK-063 to mice elevated striatal cAMP and (cGMP) levels at 0.3 mg/kg and shows potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg. TAK-063 is currently being evaluated in Clinicalal trials for the treatment of schizophrenia[1].
Kinase Assay
Catalytic assay: MEK5 protein isolated from a baculovirus expression system is used to measure kinase activity utilizing PKLight ATP Detection Reagent. The assay is performed using 15 nM GST-MEK5 and 0.75 μM ATP in assay buffer consisting of 25 mM Hepes, pH 7.5, 10 mM MgCl2, 50 mM KCl, 0.2% BSA, 0.01% CHAPS, 100 μM Na3VO4, 0.5 mM DTT and 1% DMSO in the presence of varying concentrations of BIX02188. The kinase reaction mixture is incubated for 90 minutes at room temperature followed by addition of 10 μL of an ATP detection reagent for 15 minutes. The relative light unit (RLU) signal is measured and the RLU signals are converted to percent of control (POC) values for the determination of IC50 value.
AliasTAK-063, TAK063, TAK 063
Chemical Properties
Molecular Weight428.42
FormulaC23H17FN6O2
Cas No.1238697-26-1
SmilesCOc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1
Relative Density.1.37 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 79 mg/mL (184.4 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3342 mL11.6708 mL23.3416 mL116.7079 mL
5 mM0.4668 mL2.3342 mL4.6683 mL23.3416 mL
10 mM0.2334 mL1.1671 mL2.3342 mL11.6708 mL
20 mM0.1167 mL0.5835 mL1.1671 mL5.8354 mL
50 mM0.0467 mL0.2334 mL0.4668 mL2.3342 mL
100 mM0.0233 mL0.1167 mL0.2334 mL1.1671 mL

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