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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $64 | In Stock | |
5 mg | $155 | In Stock | |
10 mg | $289 | In Stock | |
25 mg | $488 | In Stock | |
50 mg | $715 | In Stock | |
100 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $169 | In Stock |
Description | Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. |
In vitro | PT2977 effectively and dose-dependently decreased mRNA levels of human cyclin D1, a target gene regulated by HIF-2α. It leads to a rapid and dose-dependent reduction in EPO expression[1]. |
Alias | PT2977, MK-6482 |
Molecular Weight | 383.34 |
Formula | C17H12F3NO4S |
Cas No. | 1672668-24-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/mL (169.56 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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