Shopping Cart

Remove All

Your shopping cart is currently empty

Betahistine dihydrochloride

Select Batch

Purity:99.88%

Resource Download

COA HPLC HNMR

Betahistine dihydrochloride

Catalog No. T0246Cas No. 5579-84-0

Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
1 g	$50	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Betahistine dihydrochloride"

Product Introduction

Bioactivity

Description	Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.
Targets&IC50	H3 receptor:1.9 μM
In vitro	In mice, Betahistine (ED50=2 mg/kg) elevates t-MeHA levels in a dose-dependent manner. In patients with Ménière's disease, Betahistine (16 mg, twice daily for 3 months) significantly alleviates vertigo. Additionally, Betahistine (50 mg/kg) induces an upregulation of histidine decarboxylase mRNA in the nodose ganglion of the cat brain.
In vivo	In CHO(H3R) cells treated with 3 μM of, Betahistine progressively increased cAMP formation, peaking at 10 nM. Furthermore, in CHO(H3R) cells, Betahistine progressively reduced A23187-induced [3H]arachidonic acid release (EC50=0.1 nM), with the greatest effect observed at 30 nM.
Alias	PT-9, Betahistine 2HCl

Chemical Properties

Molecular Weight	209.12
Formula	C8H14Cl2N2
Cas No.	5579-84-0

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (239.1 mM)

H2O: 35 mg/mL (167.4 mM)

Ethanol: 1 mg/mL (4.78 mM)

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7819 mL	23.9097 mL	47.8194 mL	239.0972 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9564 mL	4.7819 mL	9.5639 mL	47.8194 mL
10 mM	0.4782 mL	2.3910 mL	4.7819 mL	23.9097 mL
20 mM	0.2391 mL	1.1955 mL	2.3910 mL	11.9549 mL
50 mM	0.0956 mL	0.4782 mL	0.9564 mL	4.7819 mL
100 mM	0.0478 mL	0.2391 mL	0.4782 mL	2.3910 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc