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BLU-945

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Purity:99.16%

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COA HPLC HNMR

BLU-945

Catalog No. T9754Cas No. 2660250-10-0

BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797S mutations. It is utilized in lung cancer research, including non-small cell lung cancer (NSCLC).

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Pack Size	Price	Availability
1 mg	$133	In Stock
5 mg	$339	In Stock
10 mg	$547	In Stock
25 mg	$822	In Stock
50 mg	$819	In Stock
100 mg	$1,258	In Stock

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Product Introduction

Bioactivity

Description	BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797S mutations. It is utilized in lung cancer research, including non-small cell lung cancer (NSCLC).
In vitro	BLU-945 has inhibitory activity against the EGFRm/T790M double and EGFRm/T790M/C797Striple mutants, IC50 value range from 1.2-4.4 nM[2]. BLU-945 (0- 10 mM, 4 h) inhibit EGFR phosphorylation in the EGFR L858R/T790M/C797S, and EGFR ex19del/T790M/C797S mutant cell lines[2].
In vivo	BLU-945 (oral, 0-100 mg/kg; bid) shows potent, robust EGFR pathway inhibition and anti-tumor activity in triple-mutant osimertinib-resistant Ba/F3 CDX and PDCX models[2].
Alias	BLU945, BLU 945

Chemical Properties

Molecular Weight	556.7
Formula	C28H37FN6O3S
Cas No.	2660250-10-0

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (179.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7963 mL	8.9815 mL	17.9630 mL	89.8150 mL
5 mM	0.3593 mL	1.7963 mL	3.5926 mL	17.9630 mL
10 mM	0.1796 mL	0.8981 mL	1.7963 mL	8.9815 mL
20 mM	0.0898 mL	0.4491 mL	0.8981 mL	4.4907 mL
50 mM	0.0359 mL	0.1796 mL	0.3593 mL	1.7963 mL
100 mM	0.0180 mL	0.0898 mL	0.1796 mL	0.8981 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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