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BTM-3528
🥰Excellent
Catalog No. T78875Cas No. 2054998-45-5
Alias BTM3528, BTM 3528
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis.
BTM-3528
🥰Excellent
Purity: 99.37%
Catalog No. T78875Alias BTM3528, BTM 3528Cas No. 2054998-45-5
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $485 | In Stock | |
| 5 mg | $1,090 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,670 | In Stock | |
| 50 mg | $2,180 | In Stock |
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Purity:99.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis. |
| In vitro | Both BTM-3528 and BTM-3566 demonstrated potent, dose-dependent activity against DLBCL lines of varying genotypes, including MYC-rearranged (“double” and “triple” hit) lymphomas, with growth inhibition and IC >90%50 values of 0.16–0.57 μmol/L. [2] |
| In vivo | METHODS: BTM-3566 was tested in 9 human DLBCL patient-derived xenograft (PDX) models representing ABC and GCB DLBCL subtypes, treated with 20 mg/kg BTM-3566. RESULTS: All 3 mice in 6 of the 9 PDX models achieved CR, and when 27 mice from the treatment groups across the 9 models were combined, CR was observed in 66% (19/27), with an additional 4 mice experiencing partial remission (PR), 2 mice experiencing stable tumors, and 2 experiencing progressive disease. [2] |
| Alias | BTM3528, BTM 3528 |
| Molecular Weight | 521.55 |
| Formula | C24H19F4N3O2S2 |
| Cas No. | 2054998-45-5 |
| Smiles | O=C(O)C1=C(C=2C=CC=C(F)C2)C(=NN1C3=NC(=C(S3)SC(C)C)C=4C=CC(=CC4)C(F)(F)F)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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