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BTR-1

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Purity:98%

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COA HNMR

BTR-1

Catalog No. T5822Cas No. 18331-34-5

5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.

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Pack Size	Price	Availability
1 mg	$56	In Stock
2 mg	$79	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$369	In Stock
50 mg	$531	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Product Introduction

Bioactivity

Description	5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
In vitro	5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be <10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.
Alias	5-Benzylidene-3-ethyl rhodanine

Chemical Properties

Molecular Weight	249.35
Formula	C12H11NOS2
Cas No.	18331-34-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (100.26 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0104 mL	20.0521 mL	40.1043 mL	200.5214 mL
5 mM	0.8021 mL	4.0104 mL	8.0209 mL	40.1043 mL
10 mM	0.4010 mL	2.0052 mL	4.0104 mL	20.0521 mL
20 mM	0.2005 mL	1.0026 mL	2.0052 mL	10.0261 mL
50 mM	0.0802 mL	0.4010 mL	0.8021 mL	4.0104 mL
100 mM	0.0401 mL	0.2005 mL	0.4010 mL	2.0052 mL

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