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BTR-1

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Catalog No. T5822Cas No. 18331-34-5
Alias 5-Benzylidene-3-ethyl rhodanine

5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.

BTR-1

BTR-1

🥰Excellent
Purity: 98%
Catalog No. T5822Alias 5-Benzylidene-3-ethyl rhodanineCas No. 18331-34-5
5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$98In Stock
10 mg$163In Stock
25 mg$297In Stock
50 mg$428In Stock
100 mg$591In Stock
1 mL x 10 mM (in DMSO)$112In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.
In vitro
5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be <10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.
Alias5-Benzylidene-3-ethyl rhodanine
Chemical Properties
Molecular Weight249.35
FormulaC12H11NOS2
Cas No.18331-34-5
SmilesCCN1C(=S)S\C(=C/c2ccccc2)C1=O
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (100.26 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0104 mL20.0521 mL40.1043 mL200.5214 mL
5 mM0.8021 mL4.0104 mL8.0209 mL40.1043 mL
10 mM0.4010 mL2.0052 mL4.0104 mL20.0521 mL
20 mM0.2005 mL1.0026 mL2.0052 mL10.0261 mL
50 mM0.0802 mL0.4010 mL0.8021 mL4.0104 mL
100 mM0.0401 mL0.2005 mL0.4010 mL2.0052 mL

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