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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $68 | In Stock | |
5 mg | $211 | In Stock | |
10 mg | $317 | In Stock | |
25 mg | $569 | In Stock | |
50 mg | $816 | In Stock | |
100 mg | $1,130 | In Stock | |
1 mL x 10 mM (in DMSO) | $271 | In Stock |
Description | C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM. |
In vitro | C-021 (Compound 1b) effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM). In human liver microsomes (HML), C-021 exhibits CLint value of 17,377 mL/h/kg[1]. |
In vivo | In the murine oxazolone-induced contact hypersensitivity test, the potency of C-021 is evident after subcutaneous administration. When C-021 is administered orally, however, very little inhibition is observed[1]. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice[2] |
Molecular Weight | 540.57 |
Formula | C27H43Cl2N5O2 |
Cas No. | 1784252-84-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 5.41 mg/mL (10 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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