c021 dihydrochloride

C-021 dihydrochloride is a potent CCR4 antagonist that effectively inhibits functional chemotaxis in humans and mice, with IC50 values of 140 nM and 39 nM, respectively.

C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).

Cetirizine Impurity C dihydrochloride, a specific impurity of Cetirizine, is associated with a second-generation antihistamine that serves as the carboxylated metabolite of hydroxyzine. This compound acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor [1] [2].