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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $97 | In Stock | |
5 mg | $239 | In Stock | |
10 mg | $389 | In Stock | |
25 mg | $738 | In Stock | |
50 mg | $1,150 | In Stock | |
100 mg | $1,550 | In Stock | |
1 mL x 10 mM (in DMSO) | $239 | In Stock |
Description | Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect. |
In vitro | Camlipixant (BLU-5937 ; 500 nM) blocks ATP-mediated sensitization of dorsal root ganglion (DRG) neurons.[1] |
In vivo | Camlipixant (BLU-5937 ; 3-30 mg/kg ; oral) reduces histamine and ATP-induced cough sensitization in guinea pigs.[1] Camlipixant (BLU-5937 ; 10-20 mg/kg ; i.p.) did not alter taste perception compared to control animals.[1] Camlipixant (BLU-5937) exhibits excellent drug-like properties, including good oral bioavailability, low predicted clearance in humans, no blood-brain barrier permeability, and high safety.[1] |
Alias | BLU-5937 |
Molecular Weight | 458.46 |
Formula | C23H24F2N4O4 |
Cas No. | 1621164-74-6 |
Storage | keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (49.08 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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