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cemadotin free base
Catalog No. T70407Cas No. 159776-69-9
Alias LU103793 free base
Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.
cemadotin free base
Catalog No. T70407Alias LU103793 free baseCas No. 159776-69-9
Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $190 | In Stock | |
| 5 mg | $480 | In Stock | |
| 10 mg | $687 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,480 | In Stock |
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Purity:99.69%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer. |
| Targets&IC50 | Tubulin:1 μM(Ki) |
| In vitro | Cemadotin (0-1 μM) significantly enhances the frequency of rescue while exerting minimal impact on the occurrence of catastrophes.[1] Cemadotin (0-100 μM ; 35 min) demonstrates a dose-dependent inhibition of polymerization in Tubulin-treated Strongylocentrotus purpuratus.[1] Cemadotin (0-1000 nM) selectively suppresses the rate and magnitude of tubulin growth excursions, with suppression correlating to drug concentration.[1] Cemadotin (400 pM~300 nM ; 72 h) inhibits the viability of HEK 293, F9, and HL60 cancer cells.[2] |
| Alias | LU103793 free base |
| Molecular Weight | 640.86 |
| Formula | C35H56N6O5 |
| Cas No. | 159776-69-9 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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