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CGP-20712
🥰Excellent
Catalog No. T30846Cas No. 137888-49-4
Alias UNII-SIO2UEZ19H, CGP 20712
CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.
CGP-20712
🥰Excellent
Purity: 100%
Catalog No. T30846Alias UNII-SIO2UEZ19H, CGP 20712Cas No. 137888-49-4
CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $350 | In Stock | |
| 5 mg | $828 | In Stock | |
| 10 mg | $1,130 | In Stock | |
| 25 mg | $1,590 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock | |
| 500 mg | $4,900 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM. |
| Targets&IC50 | β2-adrenoceptor:6700 nM, β1-adrenoceptor:0.7 nM |
| In vitro | In brown adipocytes, CGP-20712 (1 μM) significantly inhibited UCP1 gene expression induced by NE. However, CGP-20712 had no effect on lipolysis. These results suggested that β1-adrenoceptor mediated UCP1 gene expression.[4] In neocortical membranes, CGP 20712 exhibited affinity for β1-adrenoceptor and β2-adrenoceptor with IC50 values of 0.7 and 6700 nM, respectively.[1] |
| In vivo | CGP 20712 (a selective beta 1-adrenergic receptor antagonist) (5 mg/kg; Pretreatment of 8-day-old rats) did not change the plasma ACTH response to insulin injection.[3] |
| Alias | UNII-SIO2UEZ19H, CGP 20712 |
| Molecular Weight | 494.46 |
| Formula | C23H25F3N4O5 |
| Cas No. | 137888-49-4 |
| Smiles | CN1C(=NC(C(F)(F)F)=C1)C2=CC=C(OCC(CNCCOC3=CC(C(N)=O)=C(O)C=C3)O)C=C2 |
| Relative Density. | 1.40 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (91.01 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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