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Chelidonic acid

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Catalog No. T5558Cas No. 99-32-1
Alias γ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acid

Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.

Chelidonic acid

Chelidonic acid

🥰Excellent
Catalog No. T5558Alias γ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acidCas No. 99-32-1
Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.
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50 mg31 €In Stock
100 mg45 €In Stock
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Product Introduction

Bioactivity
Description
Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.
Targets&IC50
Glutamate decarboxylase (GAD):1.2 μM (Ki)
In vivo
Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reactions induced by ovalbumin in mice by inhibiting caspase-1 activity[3].
Animal Research
female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge.
Aliasγ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acid
Chemical Properties
Molecular Weight184.1
FormulaC7H4O6
Cas No.99-32-1
SmilesOC(=O)C1=CC(=O)C=C(O1)C(O)=O
Relative Density.1.4880 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4 mg/mL (21.72 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.4318 mL27.1592 mL54.3183 mL271.5915 mL
5 mM1.0864 mL5.4318 mL10.8637 mL54.3183 mL
10 mM0.5432 mL2.7159 mL5.4318 mL27.1592 mL
20 mM0.2716 mL1.3580 mL2.7159 mL13.5796 mL

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