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dBET1

Catalog No. T4495 CAS 1799711-21-9

dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

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dBET1, CAS 1799711-21-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 67.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 556.00
100 mg	In stock	$ 783.00
500 mg	In stock	$ 1,650.00
1 mL * 10 mM (in DMSO)	In stock	$ 155.00

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Purity: 99.3%

Purity: 98.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
Targets&IC50	BET:430 nM (EC50)
In vitro	dBET1 induced a potent and superior inhibitory effect on MV4;11 cell proliferation at 24 hours (measured by ATP content, IC50 = 0.14 μM, compared to IC50 = 1.1 μM with JQ1) consistent with the reported, pronounced inhibitory effect of RNA silencing of BRD4 in this and other models of MLL-rearranged leukemia.

Molecular Weight	785.27
Formula	C38H37ClN8O7S
CAS No.	1799711-21-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL

H2O: Insoluble

Ethanol: 5 mg/mL

References and Literature

1. Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Anti-COVID-19 Compound Library Anti-Aging Compound Library Apoptosis Compound Library Bioactive Compound Library Reprogramming Compound Library Histone Modification Compound Library Bioactive Compounds Library Max Epigenetics Compound Library

Related Products

Related compounds with same targets

Dbet57 MS402 AW68 653-47 hydrochloride Mivebresib Menin-MLL inhibitor 20 BET bromodomain inhibitor 3 (+)-JQ-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

dBET1 1799711-21-9 Chromatin/Epigenetic Epigenetic Reader Domain inhibit PROTACs Inhibitor dBET 1 dBET-1 inhibitor

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