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Dalzanemdor
🥰Excellent
Catalog No. T62839Cas No. 1629853-48-0
Alias SAGE-718
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
Dalzanemdor
🥰Excellent
Purity: 100%
Catalog No. T62839Alias SAGE-718Cas No. 1629853-48-0
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $670 | In Stock | |
| 5 mg | $1,470 | In Stock | |
| 10 mg | $1,980 | In Stock | |
| 25 mg | $2,930 | In Stock | |
| 50 mg | $3,960 | In Stock |
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Purity:100%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction. |
| In vivo | SAGE-718 (Dalzanemdor) (5), a potent and high intrinsic activity NMDAR PAM with an optimized pharmacokinetic profile for oral dosing. Compound 5 has completed phase 1 single ascending dose and multiple ascending dose clinical trials and is currently undergoing phase 2 clinical trials for the treatment of cognitive impairment in Huntington's disease.[2] |
| Alias | SAGE-718 |
| Molecular Weight | 456.62 |
| Formula | C27H43F3O2 |
| Cas No. | 1629853-48-0 |
| Smiles | C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CC[C@]([C@@](F)(F)F)(C)O)C)(CC4)[H])[H])(CC=C1C[C@@](C)(O)CC2)[H])[H] |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | chloroform: 5.68 mg/mL (12.44 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
chloroform
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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