E7046

Name: E7046
Brand: TargetMol
SKU: TQ0025
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.

Catalog No. TQ0025Cas No. 1369489-71-3

Select Batch

Purity:99.86%

Resource Download

COA LCMS LCMS LCMS HNMR HPLC

E7046

Catalog No. TQ0025Cas No. 1369489-71-3

E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$68	In Stock
25 mg	$130	In Stock
50 mg	$225	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "E7046"

Product Introduction

Bioactivity

Description	E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
Targets&IC50	EP4:23.14 nM (Ki), EP4:13.5 nM
In vitro	Through selective EP4 antagonism, E7046 reverses the immunosuppressive effects of PGE2 on activation and differentiation of human myeloid cells [1].
In vivo	E7046 (150 mg/kg) inhibits the growth of multiple syngeneic tumor models. The blockade of EP4 signaling promotes anti-tumor DC differentiation and slows tumor growth in mice. E7046 treatment reduces the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8C T cells [1]. In the CT-26 tumor model, the E7046/RT combination causes the anti-tumor memory response of 9 animals. In the 4T1 model, the combination of E7046 and RT also produces significantly better tumor growth inhibition activity compared with each treatment alone. The combination significantly improves survival by inhibiting the subsequent spontaneous lung metastasis of 4T1 tumors [2].

Chemical Properties

Molecular Weight	483.4
Formula	C₂₂H₁₈F₅N₃O₄
Cas No.	1369489-71-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (206.87 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0687 mL	10.3434 mL	20.6868 mL	103.4340 mL
5 mM	0.4137 mL	2.0687 mL	4.1374 mL	20.6868 mL
10 mM	0.2069 mL	1.0343 mL	2.0687 mL	10.3434 mL
20 mM	0.1034 mL	0.5172 mL	1.0343 mL	5.1717 mL
50 mM	0.0414 mL	0.2069 mL	0.4137 mL	2.0687 mL
100 mM	0.0207 mL	0.1034 mL	0.2069 mL	1.0343 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc