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eCF506
Catalog No. T8499Cas No. 1914078-41-3
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
eCF506
Catalog No. T8499Cas No. 1914078-41-3
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $40 | In Stock | |
| 2 mg | $57 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $126 | In Stock | |
| 25 mg | $207 | In Stock | |
| 50 mg | $369 | In Stock | |
| 100 mg | $531 | In Stock |
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Purity:98.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM) |
| Targets&IC50 | Src:< 0.5 nM) |
| In vitro | eCF506 can inhibit tyrosine kinase Src with IC50 value less than 0.5 nM. |
| In vivo | METHODS: Immunodeficient Rag2-Il2rg double knockout mice were implanted with PX459v2 and ILK gRNA 2 tumors and then given bosutinib (75 mg/kg) or eCF506 (40 mg/kg) once daily by oral gavage, and tumor volume growth was observed. RESULTS eCF506 treatment completely blocked the growth of ILK gRNA and PX459v2 tumors in the mouse model. [2] |
| Molecular Weight | 510.63 |
| Formula | C26H38N8O3 |
| Cas No. | 1914078-41-3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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