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Edonerpic maleate
🥰Excellent
Catalog No. T4422Cas No. 519187-97-4
Alias T-817MA, T-817 maleate
Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
Edonerpic maleate
🥰Excellent
Purity: 99.73%
Catalog No. T4422Alias T-817MA, T-817 maleateCas No. 519187-97-4
Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $60 | In Stock | |
| 25 mg | $123 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $328 | In Stock | |
| 200 mg | $492 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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Purity:99.73%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ). |
| Targets&IC50 | β-Amyloid peptide: |
| In vitro | Treatment with Edonerpic maleate (T-817MA) effectively preserves cortical neurons against Aβ(1-42) damage. By pre-treating for twenty-four hours and maintaining continuous exposure, Edonerpic maleate safeguards neurons from oxidative stress-induced death and nearly completely inhibits GSH reduction at both 0.1 and 1 μM concentrations. Furthermore, hippocampal slices exposed to 1 μM of Edonerpic maleate exhibit a significant increase in the generation and elongation of neurites compared to untreated controls, with notable enhancements in neurite length observed at concentrations of 0.1 and 1 μM. |
| In vivo | The post hoc analysis revealed that the average density of PSA-positive cells was significantly higher in both the vehicle and the Aβ infusion plus high-dose Edonerpic maleate (T-817MA) groups compared to the Aβ infusion control group (P<0.01). These findings suggest that the vehicle and Aβ infusion combined with high-dose Edonerpic maleate groups not only demonstrate enhanced learning capabilities in the place learning task (PLT) but also show increased neurogenesis. However, the administration of Edonerpic maleate and donepezil did not lead to a significant change in the average density of normal granule cells, indicating no notable differences in granule cell density between the Aβ infusion control group, and the groups treated with Aβ infusion plus high-dose Edonerpic maleate, Aβ infusion plus low-dose Edonerpic maleate, and Aβ infusion plus donepezil. |
| Cell Research | A cortical neuron/glia coculture is prepared. Edonerpic maleate (T-817MA) is added to the cocultures at concentrations of 0 (control), 0.01, 0.1, and 1 μM, and the cells are subsequently incubated for 5 min or 24 h. H2O2 is then added to the coculture at a concentration of 100 μM, and the cells are incubated for another 24 h. For the normal group, the preparations are maintained in the medium with neither Edonerpic maleate nor H2O2. Neuronal cell viability is quantified by measuring the Monoclonal anti-microtubule-associated protein 2 (MAP2) immunoreactivity |
| Animal Research | Edonerpic maleate (T-817MA) (high-dose: 8.4 mg/kg and low-dose: 0.84 mg/kg) and donepezil (0.5 mg/kg) are dissolved in distilled water in a volume of 5 mL/kg.Wistar rats (7 weeks, n=47) are used in this study. All rats are given food and water ad libitum in a clear cage and handled on three consecutive days before start of the experiments. The housing area is provided a temperature-controlled environment under a 12/12 h light cycle. These rats are divided into five groups: vehicle (n=11), Aβ infusion control (n=10), Aβ infusion+high-dose Edonerpic maleate (T-817MA) (8.4 mg/kg) (n=11), Aβ infusion+low-dose Edonerpic maleate (0.84 mg/kg) (n=9) and Aβ infusion+donepezil (0.5 mg/kg) (n=7) |
| Alias | T-817MA, T-817 maleate |
| Molecular Weight | 407.48 |
| Formula | C20H25NO6S |
| Cas No. | 519187-97-4 |
| Smiles | OC(=O)\C=C/C(O)=O.OC1CN(CCCOCCc2ccc3sccc3c2)C1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 155 mg/mL (380 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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