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Edonerpic maleate

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Purity:99.73%

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COA HPLC HNMR LCMS

Edonerpic maleate

Catalog No. T4422Cas No. 519187-97-4

Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

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Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$60	In Stock
25 mg	$123	In Stock
50 mg	$198	In Stock
100 mg	$328	In Stock
200 mg	$492	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
Targets&IC50	β-Amyloid peptide:
In vitro	Treatment with Edonerpic maleate (T-817MA) effectively preserves cortical neurons against Aβ(1-42) damage. By pre-treating for twenty-four hours and maintaining continuous exposure, Edonerpic maleate safeguards neurons from oxidative stress-induced death and nearly completely inhibits GSH reduction at both 0.1 and 1 μM concentrations. Furthermore, hippocampal slices exposed to 1 μM of Edonerpic maleate exhibit a significant increase in the generation and elongation of neurites compared to untreated controls, with notable enhancements in neurite length observed at concentrations of 0.1 and 1 μM.
In vivo	The post hoc analysis revealed that the average density of PSA-positive cells was significantly higher in both the vehicle and the Aβ infusion plus high-dose Edonerpic maleate (T-817MA) groups compared to the Aβ infusion control group (P<0.01). These findings suggest that the vehicle and Aβ infusion combined with high-dose Edonerpic maleate groups not only demonstrate enhanced learning capabilities in the place learning task (PLT) but also show increased neurogenesis. However, the administration of Edonerpic maleate and donepezil did not lead to a significant change in the average density of normal granule cells, indicating no notable differences in granule cell density between the Aβ infusion control group, and the groups treated with Aβ infusion plus high-dose Edonerpic maleate, Aβ infusion plus low-dose Edonerpic maleate, and Aβ infusion plus donepezil.
Cell Research	A cortical neuron/glia coculture is prepared. Edonerpic maleate (T-817MA) is added to the cocultures at concentrations of 0 (control), 0.01, 0.1, and 1 μM, and the cells are subsequently incubated for 5 min or 24 h. H2O2 is then added to the coculture at a concentration of 100 μM, and the cells are incubated for another 24 h. For the normal group, the preparations are maintained in the medium with neither Edonerpic maleate nor H2O2. Neuronal cell viability is quantified by measuring the Monoclonal anti-microtubule-associated protein 2 (MAP2) immunoreactivity
Animal Research	Edonerpic maleate (T-817MA) (high-dose: 8.4 mg/kg and low-dose: 0.84 mg/kg) and donepezil (0.5 mg/kg) are dissolved in distilled water in a volume of 5 mL/kg.Wistar rats (7 weeks, n=47) are used in this study. All rats are given food and water ad libitum in a clear cage and handled on three consecutive days before start of the experiments. The housing area is provided a temperature-controlled environment under a 12/12 h light cycle. These rats are divided into five groups: vehicle (n=11), Aβ infusion control (n=10), Aβ infusion+high-dose Edonerpic maleate (T-817MA) (8.4 mg/kg) (n=11), Aβ infusion+low-dose Edonerpic maleate (0.84 mg/kg) (n=9) and Aβ infusion+donepezil (0.5 mg/kg) (n=7)
Alias	T-817MA, T-817 maleate

Chemical Properties

Molecular Weight	407.48
Formula	C20H25NO6S
Cas No.	519187-97-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 155 mg/mL (380 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4541 mL	12.2705 mL	24.5411 mL	122.7054 mL
5 mM	0.4908 mL	2.4541 mL	4.9082 mL	24.5411 mL
10 mM	0.2454 mL	1.2271 mL	2.4541 mL	12.2705 mL
20 mM	0.1227 mL	0.6135 mL	1.2271 mL	6.1353 mL
50 mM	0.0491 mL	0.2454 mL	0.4908 mL	2.4541 mL
100 mM	0.0245 mL	0.1227 mL	0.2454 mL	1.2271 mL

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