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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $243 | In Stock | |
10 mg | $396 | In Stock | |
25 mg | $676 | In Stock | |
50 mg | $962 | In Stock | |
100 mg | $1,280 | In Stock | |
500 mg | $2,590 | In Stock |
Description | EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. |
In vitro | TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively. |
Alias | TQB3804 |
Molecular Weight | 694.6 |
Formula | C32H41BrN9O2P |
Cas No. | 2267329-76-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: Slightly soluble ![]() |
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