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EGFR-IN-7
🥰Excellent
Catalog No. T11161Cas No. 2267329-76-8
Alias TQB3804
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
EGFR-IN-7
🥰Excellent
Purity: 99.64%
Catalog No. T11161Alias TQB3804Cas No. 2267329-76-8
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $243 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $676 | In Stock | |
| 50 mg | $962 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 500 mg | $2,590 | In Stock |
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Purity:99.64%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. |
| Targets&IC50 | EGFR:0.218 nM, EGFR (WT):7.92 nM |
| In vitro | TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively. |
| Alias | TQB3804 |
| Molecular Weight | 694.6 |
| Formula | C32H41BrN9O2P |
| Cas No. | 2267329-76-8 |
| Smiles | P(C)(C)(=O)C=1C2=C(C=CC1NC3=NC(NC4=C(OC)C=C(C(C)=C4)N5CCC(CC5)N6CCN(C)CC6)=NC=C3Br)N=CC=N2 |
| Relative Density. | 1.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 0.714 mg/mL (1.02 mM), Sonication is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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