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Epoxyazadiradione
🥰Excellent
Catalog No. TN6730Cas No. 18385-59-6
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.
Epoxyazadiradione
🥰Excellent
Purity: 99.29%
Catalog No. TN6730Cas No. 18385-59-6
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $257 | In Stock | |
| 25 mg | $412 | In Stock | |
| 50 mg | $581 | In Stock | |
| 100 mg | $875 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $170 | In Stock |
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Purity:99.29%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. |
| In vitro | Epoxyazadiradione exhibits most potent anti-cancer activity in both TNBC and ER+ breast cancer cells.?Epoxyazadiradione induces apoptosis and inhibits PI3K/Akt-mediated mitochondrial potential, cell viability, migration and angiogenesis.?It also inhibits the expression of pro-angiogenic and pro-metastatic genes such as Cox2, OPN, VEGF and MMP-9 in these cells.?Furthermore, epoxyazadiradione attenuates PI3K/Akt-mediated AP-1 activation.Epoxyazadiradione suppresses breast tumor growth and angiogenesis in orthotopic NOD/SCID mice model. |
| Molecular Weight | 466.57 |
| Formula | C28H34O6 |
| Cas No. | 18385-59-6 |
| Smiles | [H][C@]12O[C@@]11[C@@](C)(CC[C@]3([H])[C@@]4(C)C=CC(=O)C(C)(C)[C@]4([H])C[C@@H](OC(C)=O)[C@@]13C)[C@@]([H])(C2=O)c1ccoc1 |
| Relative Density. | 1.25g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (128.6 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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