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Estradiol 3-sulfamate
🥰Excellent
Catalog No. T11235Cas No. 172377-52-5
Alias ES-J 995, E2MATE, BLE 00084
Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer.
Estradiol 3-sulfamate
🥰Excellent
Purity: 96.68%
Catalog No. T11235Alias ES-J 995, E2MATE, BLE 00084Cas No. 172377-52-5
Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $476 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,480 | In Stock | |
| 100 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $327 | In Stock |
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Purity:96.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer. |
| Targets&IC50 | estrone sulfatase:251 nM, estrone sulfatase:133 nM(Ki) |
| In vitro | Compared to the lead compound EMATE, Estradiol 3-sulfamate exhibits superior inhibitory activity against estrone sulfatase[1]. |
| In vivo | Estradiol 3-sulfamate readily transforms into its metabolite EMATE in the gut, making it a more effective STS inhibitor[2]. |
| Alias | ES-J 995, E2MATE, BLE 00084 |
| Molecular Weight | 351.46 |
| Formula | C18H25NO4S |
| Cas No. | 172377-52-5 |
| Smiles | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(OS(N)(=O)=O)cc3CC[C@@]21[H] |
| Relative Density. | 1.319 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (142.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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