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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $147 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $476 | In Stock | |
25 mg | $953 | In Stock | |
50 mg | $1,480 | In Stock | |
100 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $327 | In Stock |
Description | Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer. |
Targets&IC50 | estrone sulfatase:133 nM(Ki), estrone sulfatase:251 nM |
In vitro | Compared to the lead compound EMATE, Estradiol 3-sulfamate exhibits superior inhibitory activity against estrone sulfatase[1]. |
In vivo | Estradiol 3-sulfamate readily transforms into its metabolite EMATE in the gut, making it a more effective STS inhibitor[2]. |
Alias | E2MATE, BLE 00084, ES-J 995 |
Molecular Weight | 351.46 |
Formula | C18H25NO4S |
Cas No. | 172377-52-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (142.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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