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Ethaverine hydrochloride
Catalog No. T0369Cas No. 985-13-7
Alias Papetherine, Ethaquin, Consenil
Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2]
Ethaverine hydrochloride
Catalog No. T0369Alias Papetherine, Ethaquin, ConsenilCas No. 985-13-7
Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $39 | In Stock | |
| 5 mg | $60 | In Stock | |
| 10 mg | $109 | In Stock | |
| 25 mg | $202 | In Stock | |
| 50 mg | $360 | In Stock | |
| 100 mg | $568 | In Stock | |
| 500 mg | $1,230 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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CitedSelect Batch
Purity:99.90%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2] |
| In vitro | METHODS: The inhibitory effect of ethaverine on dopamine content in PC12 cells was studied. RESULTS Ethaverine reduced dopamine content in PC12 cells in a concentration-dependent manner. At a concentration of 1.0 μM, dopamine content was inhibited by 33.6% within 24-48 hours. The IC50 value of ethaverine was 1.4 μM. 2.0 μM ethaverine reduced dopamine content after 6 hours of action. Tyrosine hydroxylase (TH) was inhibited after 6 hours of ethaverine treatment in PC12 cells, and the activity remained at a reduced level until 36 hours (the inhibition rate was 12-22% at 2.0 μM). [1] Ethaverine (10 μM) treatment in PC12 cells reduces catecholamine secretion by blocking L-type voltage-sensitive Ca2+ channels. [2] |
| In vivo | METHODS: In a short-term experiment on 11 guinea pigs, the effect of Ethaverine hydrochloride on cochlear microcirculation was observed (2/5 and /10 mg/kg, i.v) for 10 minutes. In these experiments, intracochlear PO2, intracochlear potential (EP), cochlear microphonic (CM) potential, and blood pressure (BP) were recorded. Intracochlear PO2 was measured polarographically in the mid-level using gold electrodes. RESULTS Ethaverine hydrochloride at doses of 5 and 10 mg/kg caused a significant increase in intracochlear PO2 for 35 to 90 minutes, even with a temporary decrease in blood pressure. At the same time, this improvement in cochlear microcirculation was observed to coincide with an increase in CM potential. The decrease in EP may be the result of a decrease in blood pressure and a direct effect of Ethaverine hydrochloride on EP production. [3] |
| Alias | Papetherine, Ethaquin, Consenil |
| Molecular Weight | 431.96 |
| Formula | C24H30ClNO4 |
| Cas No. | 985-13-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (231.5 mM)  DMSO: 45 mg/mL (104.18 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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