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ETP-46464

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Purity:99.56%

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COA HNMR HPLC

ETP-46464

Catalog No. T2084Cas No. 1345675-02-6

ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$89	In Stock
25 mg	$178	In Stock
50 mg	$289	In Stock
100 mg	$463	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description

ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).

In vivo

ETP-46464 (1 μM) exhibits inhibitory effects on the G2/M phase checkpoint induced by ionizing radiation, resulting in cells with micronuclei or completely fragmented nuclei. It significantly enhances the toxicity in p53-deficient cells, particularly under replicative stress conditions like cyclin E overexpression, intensifying the toxicity. At a concentration of 100 nM, ETP-46464 can fully inhibit ATR activity. Furthermore, ETP-46464 inhibits the activity of PI3Kα (IC50: 170 nM), mTOR (IC50: 0.6 nM), and DNA-PKcsmTOR (IC50: 36 nM) proteins. It promotes damage due to replication fork stalling and induces extensive DNA damage in replicating cells.

Chemical Properties

Molecular Weight	470.52
Formula	C30H22N4O2
Cas No.	1345675-02-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 6 mg/mL (12.75 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1063 mL	0.5313 mL	1.0627 mL	5.3133 mL
50 mM	0.0425 mL	0.2125 mL	0.4251 mL	2.1253 mL
100 mM	0.0213 mL	0.1063 mL	0.2125 mL	1.0627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc