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Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $58 | In Stock | |
10 mg | $103 | In Stock | |
25 mg | $173 | In Stock | |
50 mg | $260 | In Stock | |
100 mg | $377 | In Stock | |
200 mg | $523 | In Stock | |
1 mL x 10 mM (in DMSO) | $88 | In Stock |
Description | Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). |
Targets&IC50 | mGluR5 (rat):54 nM (kd), mGluR5 (human):31 nM (kd) |
In vivo | Fenobam sulfate (30-60 mg/kg; p.o.) significantly inhibited cocaine self-administration [3]. |
Molecular Weight | 266.68 |
Formula | C11H11ClN4O2 |
Cas No. | 57653-26-6 |
Smiles | CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1 |
Relative Density. | 1.47 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (206.24 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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