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FGI-106 tetrahydrochloride
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
Catalog No. T11281LCas No. 1149348-10-6
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Purity:98.98%
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FGI-106 tetrahydrochloride
Catalog No. T11281LCas No. 1149348-10-6
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $79 | In Stock | |
| 5 mg | $173 | In Stock | |
| 10 mg | $273 | In Stock | |
| 25 mg | $452 | In Stock | |
| 50 mg | $636 | In Stock | |
| 100 mg | $858 | In Stock | |
| 200 mg | $1,150 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $230 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential. |
| Targets&IC50 | EBOV:（EC50）100 nM , DENV: 400-900 nM , HCV: 200 nM , HIV-1:150 nM , Rift Valley virus: 800 nM |
| In vitro | In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. |
| In vivo | FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner. |
| Molecular Weight | 604.48 |
| Formula | C28H42Cl4N6 |
| Cas No. | 1149348-10-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/ml (12.41 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
feverpathogensEbolaInfluenza VirusinhibitHIV-1replicationFGI 106 TetrahydrochlorideHCVhemorrhagicHepatitis C virusEBOVHIVtetrahydrochlorideFGI106 tetrahydrochlorideFGI106 TetrahydrochlorideInhibitorFGI-106 tetrahydrochlorideFGI-106broad-spectrumantiviralHuman immunodeficiency virusFGI-106 TetrahydrochloridelethalFGI106FGI 106 tetrahydrochlorideFGI 106
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