lethal

Benzyl benzoate (Benzoic acid benzyl ester) is one of the older preparations used for the therapy of scabies. Scabies is a skin infection caused by the Sarcoptes scabiei. Its symptoms are red spots, severe itching (particularly at night), and may lead to a secondary infection. Benzyl benzoate is useful in the therapy of scabies because it is lethal to this mite. It is also used for the therapy of lice affection of the body and head. Benzyl benzoate is not the therapy of choice for scabies because of its irritant properties.

Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s

Paraherquamide E is a fungal metabolite originally isolated from P. charlesii with anthelmintic and insecticidal activities. It is lethal to C. elegans [LD50 = 6 μg ml] and O. fasciatus [LD50 = 0.089 μg nymph]. Oral administration of paraherquamide E [0.5-4 mg kg] reduces T. colubriformis fecal egg count in gerbils.

8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mg L against P. redivivus.

(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian pest damage.

Bombinin H7, an antimicrobial peptide originating from the skin secretions of Bombina, exhibits bactericidal activity against Bacillus megaterium Bm11 at a lethal concentration of 25.2 μM [1].

Bombinin H4, an antimicrobial peptide from the skin of the moth species Bombina variegata, exhibits potent bactericidal activity with lethal concentrations of 4.8 μM against Escherichia coli D21 and 3.3 μM against Staphylococcus aureus Cowan 1 [1].

Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic

Bombinin H1, an antimicrobial peptide originating from the skin of the Bombina variegata moth, exhibits lethal concentrations of 3.8 μM against Escherichia coli D21 and 2.1 μM against Staphylococcus aureus Cowan 1 [1].

Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly enhances survival in mice facing lethal Staphylococcus aureus infections through its antimicrobial and immunoregulatory functions [1].

1. Naringenin trimethyl ether (5,7,4'-Trimethoxyflavanone) shows significant molluscicidal activity with a median lethal concentration (LC(5)) of 3.9 μg/mL.

Bombinin H3, an antimicrobial peptide sourced from the Bombina variegata (moth) skin, exhibits lethal concentrations of 3.7 μM and 2.4 μM against Escherichia coli D21 and Staphylococcus aureus Cowan 1, respectively [1].

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).[2] It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.[1]

Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes